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Robust, cell cycle-coupled cytokinesis in mutant cells lacking myosin II
Species name:Dictyostelium discoideum
National Institute of Advanced Industrial Science and Technology Taro Uyeda
The cellular slime mold Dictyostelium discoideum has two cell-cycle coupled methods of cytokinesis. Mutant cells lacking myosin II cannot divide in suspension, and become multinucleate. On substrates, however, these mutant cells divide efficiently, due to oppositely-directed traction forces generated along the two polar regions (cytokinesis B). Note that all the nuclear division events, visualized by GFP-histone, are followed by cell division (circled).
Genetic and morphological evidence for two parallel pathways of cell cycle-coupled cytokinesis in Dictyostelium. J. Cell Sci., 115: 2241-2251.
Variations on a Theme - the Many Modes of Cytokinesis. Curr. Opin. Cell Biol., 16:55-60